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Electrical stimulation of the OB induces electrophysiological responses in the LH and the PVN 36,37 , many of the structures to which the OB projects via the MCs, such as the AON, the olfactory tubercle and the piriform cortex, also project to the LH 37,38,39

Taken together, these biophysical and pharmacokinetic limitations help explain why engineered GLP-1producing strains demonstrate substantial efficacy in mice yet are unlikely to achieve comparable effects under clinical conditions

Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger

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