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As of May 2026, compounded semaglutide may only be prepared when all applicable federal and state compounding requirements are met, including an individualized patient prescription and restrictions against compounding products that are essentially copies of commercially available FDA-approved drugs

[3] Neutral endopeptidase 24.11 (NEP 24.11) is a membrane-bound zinc metallopeptidase widely expressed in several tissues, but found in particularly high concentrations in the kidneys, which is also identified accountable for the rapid degradation of GLP-1