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297,298,299,301 Subsequent trials in patients with T2D and established HF showed that dapagliflozin and empagliflozin reduced the composite outcomes of worsening HF (defined as hospitalization for HF or an urgent visit for HF) or cardiovascular death by 2126%

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In preliminary results of OASIS 1, a recent 68-week, phase 3a clinical trial that compared once-daily oral semaglutide with placebo in adults with obesity or overweight with one or more underlying comorbidities, the average weight loss from baseline was 15.1% in the semaglutide group and 2.4% in the placebo group

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