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In STEP 1, a 68-week double-blind trial of 1,961 adults with obesity, or with overweight plus at least one weight-related coexisting condition and without diabetes, once-weekly subcutaneous semaglutide 2.4 mg produced a mean change in body weight of 14.9% versus 2.4% with placebo, an estimated treatment difference of 12.4 percentage points

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This article covers the specific biological mechanisms that create uncertainty, the animal model findings that drive current washout recommendations, and the research design protocols labs use when pregnancy becomes a variable in peptide studies

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