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Unlike treatment with GLP-1RAs, which generally leads to body weight and fat mass reduction, pioglitazone dose-dependently increases body weight and fat mass

The time of day is flexible as a subcutaneous injection, retatrutide is not subject to the same food-related absorption considerations as oral medicines

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Quantification and statistical analysis Statistical analyses were performed using GraphPad Prism 10.1.1 (GraphPad) and figures were generated using either GraphPad Prism or CorelDraw X8 (Corel)