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We know that macrocytosis is a very, very late stage of B12 deficiency and that severely deficient patients may not present with this sign, the administration of folic acid also masks macrocytosis by normalising the size of the blood cells

It ensures the DNA synthesis and adequate maturation of the red blood cells, ensuring their right size, shape, and functioning

Bone Density: Mouse model studies have also linked IGF-1 signaling to improvements in bone density and skeletal strength, suggesting systemic health benefits beyond just muscular development