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Whilst 510% of patients taking VPA may develop a transient alanine transaminase rise, numerous cases of acute liver injury presenting with jaundice and progression to fatal liver failure have been reported, with most cases occurring within the first 6 months of treatment

Situaciones que requieren atencin mdica inmediata: Debe buscar atencin de emergencia si experimenta signos de toxicidad heptica , que pueden incluir: ictericia (coloracin amarillenta de piel u ojos), orina oscura, heces de color claro, dolor abdominal superior derecho severo, confusin inexplicable, o fatiga extrema

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