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Peroxisomes are uniquely suited to initiate the shortening of very-long-chain and structurally complex fatty acids that are inefficient substrates for mitochondria, whereas mitochondria complete downstream oxidation and ATP-linked energy production

If a Sulfanomide allergy we continue with thiol therapy but start low in case they are one of those cross reactors (which is rare but not unheard of).

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Detachment of cytochrome c from cardiolipin might also be triggered by increased cytosolic calcium, which weakens the electrostatic interaction between cytochrome c and cardiolipin and further generates ROS via MPT