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Patients reported high acceptability of these tools, citing increased convenience and enabled personalized tracking of symptoms and treatment responses 21

Authors concluded that, in the process of prostate carcinogenesis, activating histone modifications on GSTP1 are lost and subsequently DNA becomes methylated and inaccessible resulting in transcriptional silencing thus demonstrating interplay between histone reprogramming and promoter region methylation (Okino et al., 2007)

This damage likely accelerates protein turnover, thereby impairing the energy-generating capacity of mitochondria

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