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GLP-1R activation has a significant effect on glycemic control in patients with T2DM through a variety of mechanisms, including stimulation of insulin secretion, inhibition of glucagon secretion, protection of -cells from apoptosis, slowing gastric emptying and increasing satiety (Drucker, 2006)

GLP-1 exerts its effects through the GLP-1 receptor, which is found in various tissues, including the brain, pancreas, stomach, heart, kidneys, and adipose tissue [14, 15]

Differences in skeletal maturation may further contribute, as females reach skeletal maturity earlier than males, rendering the timing of CR relative to growth phases critical for site-specific vulnerability

For example, scientists are developing GLP-1 drugs that require only monthly injections