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The number of Medicaid prescriptions and gross spending on GLP-1s have increased substantially since 2019 (Figure 2)

For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors

It works by blocking an enzyme called NNMT, which slows down metabolism and fat burn

However, an underlying assumption in this analysis is that patients will comply with oral therapy