In an APP/PS1 model of AD, D-Ala2-GIP reduced activation of chronic inflammatory response in the brain, oxidative stress, synapse loss, amyloid plaque burden, and DNA damage [106]
In private online gatherings, Facebook groups, and Zoom sessions, distributors are trained to promote Protandims purported ability to reduce oxygen-free radicals, and to suggest that scientific evidence supports a broad spectrum of potential benefits
Use of the product is not likely to cause adverse health consequences
Consequently, clinical communication can shift from binary assertions (effective/ineffective, safe/unsafe) to a framework of probabilities + intervals + acceptance thresholds. For instance, the posterior probability of reaching a clinically meaningful weight-loss threshold can be presented alongside the posterior uncertainty of benefits in hard reproductive endpoints, rather than replacing the decision process with a single P -value