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Recent findings also implicate betaine in the modulation of gut microbiota composition, an emerging determinant in the pathophysiology of NAFLD

For the aforementioned reasons, the maintenance of high concentrations of GSH is vital for most types of cell, since it plays important roles in the control of biological process, including metabolic detoxification, protein folding, vitamin regeneration, mitochondrial health, immune defense against viruses, cellular proliferation regulation, apoptosis, and redox balance, among others

Given the significant unmet need for novel therapeutic interventions in AS, particularly as many patients still progress to KF despite current treatments like RASi, GLP-1 RAs may offer an innovative strategy to delay KF in AS, potentially addressing both metabolic and inflammatory pathways involved in CKD progression [40, 42, 56]

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