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Together, these data suggested that activating GLP-1R alleviated glycolysis, at least partially by the suppression of PFKFB3-driven glycolysis, and attenuated lactate-mediated histone lactylation, which in turn suppressed the transcription of profibrotic genes in TGF-1 + IL-1-challenged fibroblasts

In the elegant mouse KO experiments by Efstradiadis et al (21), KO of the IGF2R resulted in fetal overgrowth

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The necessary studies would require robust and reproducible methodologies for creating multiple analogues in quantities sufficient for biological assays