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Volkova A et al., 2016 [PubMed] Key Areas of Research: Molecular Tuftsin receptor binding characterization, GABAergic gene expression profiling, peptide structural stability assays in biological matrices, angiotensin-converting enzyme interaction mapping, enzymatic cleavage resistance characterization Cellular / Neurochemical GABAergic signaling pathway characterization, inhibitory neurotransmission parameter assessment, neuroblastoma cell line gene expression profiling, GABA receptor interaction modeling, anxiolytic-relevant receptor system characterization in preclinical settings Systemic (Preclinical) Behavioral parameter measurement in anxiety-relevant preclinical models, cytokine pathway modulation monitoring, neuroimmune axis interaction characterization, inhibitory signaling system profiling in controlled investigational settings Together, these findings suggest broad experimental potential for Selank across GABAergic neurotransmission, neuroimmune signaling, and preclinical anxiety-model research pathways
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The plaintiffs had asked the panel to create a separate multi-district litigation for the cases, arguing that the optic neuropathy cases deal with different medical issues and evidence than other lawsuits claiming the drug can cause gastroparesis, a paralysis of the gastrointestinal tract
