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Atherosclerosis progression, as a chronic inflammatory mechanism, is characterized by immune system dysregulation associated with increased pro-inflammatory cytokine production, including interleukin 6 (IL-6), tumor necrosis factor- (TNF-), and IL-1, as well as pattern recognition receptor proteins like CRP (170, 261267)

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Co-treatment with RESV in endothelial cells (HUVECs) treated with serum from PE pregnant women restored the levels of heme oxygenase-1 (HO-1) and nitric oxide (NO) markers [36], key factors for placental vasculature and endothelial protection [55,56]

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