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Regeneration of Other Antioxidants Glutathione directly recycles and regenerates other antioxidants that have been oxidized and inactivated: Vitamin C (ascorbate): GSH reduces dehydroascorbate back to ascorbate Vitamin E (alpha-tocopherol): GSH supports regeneration of oxidized tocopheryl radical Alpha lipoic acid (ALA): GSH participates in maintaining ALA in its reduced form This regenerative cascade is what distinguishes glutathione from most other antioxidants

Zhang M, Cui S, Mao B, Zhang Q, Zhao J, Zhang H, et al

High levels of sugar in the blood (hyperglycemia) and insulin deficiency or resistance can lead to increased oxidative stress

(2014) 69:S49