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Munasinghe and the staff at Nawaloka Chemical Pathology Laboratory for their assistance.
46,47,48 In 2005, the discovery of pseudouridine () modification addressed the immunogenicity issue of in vitro-synthesized mRNA, 49 leading to the initiation of the first human trial of an mRNA vaccine against melanoma in 2008
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However, the levels of cyanide resulting from cyanocobalamin are so minimal that the term toxic is hardly applicable here Build up in the cells: studies have shown that around 1000 g of cyanocobalamin accumulates in the cell fluid during therapy with high dosages (2)
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