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Our findings confirm that longer diabetes duration is associated with a lower glycaemic response to GLP-1 RAs [3, 6, 16], probably due to declining beta cell function, as intact insulin secretion is necessary for a robust glycaemic response to this drug class [1, 3]

Prescription GLP-1 Medications: Mechanism, Cost, and Clinical Evidence GLP-1 receptor agonists (semaglutide, tirzepatide) work by increasing satiety signals in the brain, slowing gastric emptying, and improving insulin secretion

The trial included 529 patients from 13 countries in Europe, North America, South America and Asia