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Additionally, they are all broken down similarly by dipeptidyl peptidase-4 (DPP-4) though GIP breakdown occurs at a slower rate than GLP-1 breakdown [16]

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By simultaneously activating GLP-1, GIP, and glucagon receptors, it allows researchers to investigate receptor cross-talk, intracellular cascades, and their role in glucose regulation, lipid metabolism, and energy homeostasis

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