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If a patient does smoke on the day of surgery, it should be at least two hours before the procedure, according to the American Society of Regional Anesthesia and Pain Medicine, because smoking marijuana can significantly increase heart rate and blood pressure within the two hours following use, and it may increase the patients risk of suffering a surgery-related heart attack. It's also unclear when its safe to resume marijuana use following surgery

Khadimallah I, Jenni R, Cabungcal J-H, Cleusix M, Fournier M, Beard E, et al

Increased p53 acetylation promotes cardiomyocyte apoptosis in models of diabetic cardiomyopathy and heart failure

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