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35,36 Dominski et al

(2014) 348:g2183

In the context of diabetes and renal complications, oxidative stress stimulates glomerular fibrosis mediated by TGF-, while antioxidants such as alpha-lipoic acid have been shown to inhibit the activity of NADPH oxidase (especially NOX4), attenuating renal damage induced by hyperglycemia and inflammation [91]

Challenges in validation of combination treatment strategies for CRC using patient-derived organoids