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Readers should weigh the recommendations with this context, noting that the underlying anatomical and mechanistic observations are independently corroborated by other sources

According to NICE Technology Appraisal 875, Wegovy should be prescribed within a specialist weight management service, with a maximum treatment duration of 2 years, and continued only if at least 5% weight loss is achieved at 6 months

Second, and most importantly, muscle and heart have a low capacity for activating medium-chain fatty acids to coenzyme A (CoA), which is a prerequisite step for fatty acid -oxidation

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