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2014, 13:142 GLP-1R Signaling Binding of GLP-1 to GLP-1R triggers a downstream signaling cascade that induces a potent stimulation of glucose induced insulin secretion (GIIS) in pancreatic beta-cells, as well as inhibition of alpha cell glucagon release (6)

If lean mass is dropping faster than expected, we adjust the protocol: higher protein, modified training, or dose adjustment

The SURMOUNT trials demonstrated up to 22.5% mean weight loss at the highest dose