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Peroxisomal H 2 O 2 metabolism is usually related to the regulation of peroxisomal functions and is also important for extra-peroxisomal redox targets, such as FOXO3, the master regulator of ROS

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Slightly reduced GLP-1 concentrations after a meal in participants with impaired oral glucose tolerance and more severely impaired GLP-1 secretion in type 2 diabetic patients, as demonstrated in cross-sectional analyses, may translate into a progressive loss of the ability to secrete GLP-1 with advancing type 2 diabetes as part of the process of disease progression