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Common effects: Dizziness Hypotension Fatigue Hyperkalemia Headache Less common but notable: Renal impairment Angioedema (rare) GI upset Contraindications Pregnancy (teratogenic) Bilateral renal artery stenosis Severe hepatic impairment History of angioedema with ARBs (rare) Cautions Monitor potassium & creatinine Use carefully with: Potassium-sparing diuretics NSAIDs ACE inhibitors Lithium Benefits Over ACE Inhibitors No dry cough Lower chance of angioedema Good renal protection Patient Advice Take at the same time each day Report dizziness or swelling Avoid potassium supplements unless advised Regular kidney function and BP monitoring Brand Names Cozaar Losacar Aprovasc (with amlodipine) Hyzaar (with hydrochlorothiazide) To view or add a comment, sign in What is Diabetic Ketoacidosis

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Multiple regression analysis identified that 1) eGFR at the time of drug addition, 2) change in HbA1c from at the time of drug addition to the final observation, and 3) the preceding of SGLT2i were independent and significant determinants of eGFR decline