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The major causes fall into three broad categories: Increased bilirubin production (hemolysis or ineffective erythropoiesis): Hemolytic anemias (intravascular or extravascular) Autoimmune hemolytic anemia (AIHA) Hereditary spherocytosis, elliptocytosis G6PD deficiency Sickle cell disease Thalassemia Ineffective erythropoiesis Vitamin B12 or folate deficiency (megaloblastic anemia) Myelodysplastic syndromes Thalassemia major Impaired hepatic uptake : Gilbert syndrome decreased activity of UDP-glucuronosyltransferase (UGT1A1)

A better understanding of the microbiome-immune system interactions will help us develop more targeted, specific antitumor medications in the future

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