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Thus, GSH plays the role of a mediator in crucial cellular processes, such as cell cycle progression and programmed cell death ( The GSH itself is created from amino acids, including glutamate, L-cysteine, and glycine, through two ATP-dependent enzymatic reactions mediated by -glutamylcysteine synthetase (-ECS or also known as GSH1) and GSH synthetase (GS or also named GSH2) ( Figure 1 )

Immunologic basis for allopurinol-induced severe cutaneous adverse reactions: HLA-B*58:01-restricted activation of drug-specific T cells and molecular interaction

Redox-metabolite concentrations follow normal distribution The metabolite distributions in the blood samples typically followed a normal distribution across both genders, with no significant age-related changes in the whole population (Fig