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A secondary passive diffusion pathway allows approximately 1% of ingested B12 to be absorbed directly across the intestinal mucosa, independent of intrinsic factor

HPLC (High-Performance Liquid Chromatography) An analytical chemistry technique used to verify the identity and purity of peptide compounds

There is a real physiological argument, though one that should be taken with appropriate skepticism until human data accumulates, about receptor downregulation and what hitting three pathways at maximum dose may do to the bodys endogenous signaling architecture over years of continuous use