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2011 Jul;66(7):893-902

We hypothesized that disrupting this tether or lengthening the linker that connects the two -CTs may uncouple the two binding sites in the active state of IGF1R, reduce the negative cooperativity, and allow the binding of the second IGF1

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Improved HbA1c: GLP-1 drugs consistently reduce HbA1c an important long-term marker of diabetes control often by 11.5%, depending on the agent and dose