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This represents a paradigm shift in non-surgical obesity treatment

The 5-year risk of CKD was about 7% with SGLT2 inhibitors versus just over 8% with GLP-1s, suggesting a slight edge for SGLT2 inhibitors on pure kidney outcomes

By leveraging the capabilities of biological systems, such as enzymes, microorganisms, and genetic engineering tools, researchers can overcome challenges in traditional synthetic chemistry and unlock new opportunities for drug discovery, and chemical manufacturing

J Physiol 591(23):60396052