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Some cancers (particularly those with IGF-1 receptor expression) may warrant caution even after remission Diabetic retinopathy: GH can worsen proliferative retinopathy Pregnancy/breastfeeding: Safety not established Uncontrolled diabetes: GH can temporarily worsen blood sugar control

This synergy is exemplified by transmembrane protein 164 (TMEM164), which promotes autophagy-dependent ferroptosis in NSCLC