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Glossary 4-HNE 4-Hydroxynonenal ACSL4 Acyl-CoA Synthetase Long-Chain Family Member 4 ATP Adenosine Triphosphate BALF Bronchoalveolar Lavage Fluid BMSC Bone Marrow Mesenchymal Stem Cell cAMP Cyclic Adenosine Monophosphate COPD Chronic Obstructive Pulmonary Disease CS Cigarette Smoke DAMPs Damage-Associated Molecular Patterns DRP1 Dynamin-Related Protein 1;EMT, Epithelial-Mesenchymal Transition ER Endoplasmic Reticulum ETC Electron Transport Chain FPN/SLC40A1 Ferroportin FSP1 Ferroptosis Suppressor Protein 1 FTH1 Ferritin Heavy Chain 1 FTL Ferritin Light Chain GPX4 Glutathione Peroxidase 4 GSH Glutathione HMGB1 High Mobility Group Box 1 HO-1 Heme Oxygenase-1 IFN- Interferon-gamma IL Interleukin IRP1/2 Iron-Responsive Element-Binding Protein 1/2 ISC Iron-Sulfur Cluster LABA Long-Acting Beta2-Agonist LAMA Long-Acting Muscarinic Antagonist LDs Lipid Droplets lncRNA Long Non-coding RNA LOX Lipoxygenase LPCAT3 Lysophosphatidylcholine Acyltransferase 3 LPS Lipopolysaccharide MAPK Mitogen-Activated Protein Kinase MDA Malondialdehyde NETs Neutrophil Extracellular Traps NF-B Nuclear Factor Kappa B NLRP3 NLR Family Pyrin Domain Containing 3 NOX4 NADPH Oxidase 4 Nrf2 Nuclear Factor Erythroid 2-Related Factor 2 NCOA4 Nuclear Receptor Coactivator 4 PBMCs Peripheral Blood Mononuclear Cells PD-1 Programmed Cell Death Protein 1 PD-L1 Programmed Cell Death Ligand 1 PDE4 Phosphodiesterase 4 PPAR Peroxisome Proliferator-Activated Receptor Gamma PUFAs Polyunsaturated Fatty Acids ROS Reactive Oxygen Species SLC3A2 Solute Carrier Family 3 Member 2 SLC7A11 Solute Carrier Family 7 Member 11 System Xc Cystine/Glutamate Antiporter System TGF- Transforming Growth Factor Beta Th17 T Helper 17 Cell TIM-3 T cell Immunoglobulin and Mucin domain-containing protein 3 TfR1 Transferrin Receptor 1 TLR4 Toll-Like Receptor 4 Tregs Regulatory T Cells UPR Unfolded Protein Response

When pain persists beyond three months, when ultrasound shows structural degeneration, or when conservative measures have plateaued that's when we escalate

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