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doi: 10.1016/j.jcjd.2022.11.006, 36

Because the intranasal forms have lower absorption than the IM dosage form, intranasal B12 forms are administered once weekly

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hypothesized the central role of acrolein in the disruption of the structure of cell membranes in RBCs (changes in the cell membrane, cytosolic proteins, and osmotic sensitivity)