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It has been shown that roGFP2 is almost fully reduced in intact tissues and that a treatment with the GSH1 inhibitor BSO or the electrophilic xenobiotic 1-chloro-2,4-dinitrobenzene led to fully oxidized state of the biosensor accompanied by decreased fluorescence intensity 52

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Clinical Guidelines and Research Evidence Leading medical organizations, such as KDIGO (Kidney Disease: Improving Global Outcomes) and the American Diabetes Association, endorse GLP-1 receptor agonists for individuals with type 2 diabetes and CKD