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patient in intramuscular arm provide appointments for injections Visit 2 (week 8) Anamnesis: record lifestyle habits and use of alcohol Symptoms: if pathological at the first visit, record paresthesia, asthenia, loss or reduction of appetite, sadness or change in level of happiness, and concomitant pharmacological treatment Physical examination: if pathological at the first visit examine for Hunters glositis, positional and vibrational sensitivity Record concomitant treatment Request analyses to be performed one week before next visit: haemogram and serum vitamin B12 Questionnaires: EuroQoL-5D Assessment of adverse effects Therapeutic plan: patient in oral arm provision of medication

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The route that applies depends on the substance and its regulatory status

The log 10 LDA score threshold was set to 2.0, and all classes were compared against all other classes for multi-class analysis