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As illustrated in Figure 1, MetS is associated with an elevation in oxidative stress, which is the underlying cause of various complications such as atherosclerosis, hypertension, myocardial infarction, and inflammation

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Specifically, this meta-analysis combined the results of 19 clinical trials of vitamin E supplementation that mostly focused on secondary prevention and, as such, included subjects with pre-existing conditions, including heart disease, end-stage renal failure, and Alzheimer's disease