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This is due not only to the structural similarity between insulin and the IGFs, but also to the high degree of homology between the insulin receptor (IR) and the IGF receptors (Figure 1)

Several Phase II studies on enclomiphene have shown some interesting results: not only did it help increase testosterone levels, but it also had an unexpected effect: it lowered levels of another hormone called IGF-1

Cancer 120 , 10901098 (2019)

Phase 3 completion is projected for late 2025, though trial timelines frequently extend beyond initial projections