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No controlled trials exist in pregnant women for ethical reasons, so the FDA's cautious approach is based on animal data plus the principle that avoidable medication exposure during pregnancy should be minimized

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Moreover, folic acid supplementation lowered homocysteine and improved arsenic methylation capacity among environmentally arsenic-exposed Bangladeshi adults who presented initially with low betaine and choline status (Bozack et al, 2020)

[DOI] [PMC free article] [PubMed] [Google Scholar] 203.Nguyen H.N., Wey S.P., Juang J.H., Sonaje K., Ho Y.C., Chuang E.Y., Hsu C.-W., Yen T.-C., Lin K.-J., Sung H.-W