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Messer also shares a glimpse of her patients' nutrition plan, which considers the side effects patients may incur: "[Since] Semaglutide has the potential to cause constipation, nausea, and reflux, I preemptively place my patients on high-fiber, low-fat, calorie-restricted diets to minimize the risk of these side effects

This occurs because GLP-1 receptor activation affects appetite centers in the brain, reduces energy intake, and accelerates metabolic adaptationprocesses that can lower core body temperature regulation and reduce insulating body fat mass

Food Quality Can Impact Metabolic Health Independent of Calorie Intake Metabolic health can improve even without reducing total calorie intake