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40 Nevertheless, accumulating evidence indicates that CR is detrimental to skeletal metabolism, as evidenced by reductions in BMD and bone mineral content (BMC), diminished bone formation indices (e.g., bone formation rate, osteoblast number), and a concomitant increase in bone resorption

While it may help increase natural testosterone in men with obesity-related low T, men with primary hypogonadism or clinically documented testosterone deficiency still require TRT for adequate hormone restoration

But heres what the 2026 data shows: people who stop these medications regain about two-thirds of the weight within a year on average, and many say the hardest part is the food noise coming back

Sustainable weight loss strategies still exist, simpler food choices, steady exercise, better sleep, and honest medical review