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However, some of the more recent ones, like liraglutide (Larsen et al., 2017), semaglutide, and, in particular, tirzepatide (trade name Mounjaro) have shown good research data suggesting that they can produce a substantial amount of weight loss in addition to correcting things like glucose tolerance and also assisting with decreasing lipid abnormalities (Flory & Lipska, 2019)

Genetic Basis and Pathophysiology Most cases of MH are associated with mutations in the RYR1 gene , which encodes the ryanodine receptor type 1 (RyR1) calcium-release channel in skeletal muscle

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