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Phase 3 trials involve thousands of participants over longer periods specifically to find problems that smaller trials miss

Tolerability and pharmacokinetics of metformin and the dipeptidyl peptidase-4 inhibitor sitagliptin when co-administered in patients with type 2 diabetes

That 2.7 percentage point gap suggests prior receptor exposure may genuinely reduce subsequent responsiveness

Funding This work was sponsored by grants from the National Key Research and Development Program of China (2023YFC2508106), National Natural Science Foundation of China (No