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[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Montero-Moran G, Caviglia JM, McMahon D, Rothenberg A, Subramanian V, Xu Z, et al

Curcumin, at doses that achieve a hormetic effect (e.g., 10 mg/L or approximately 28 M in vitro ), can enhance antioxidant defense by activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, upregulating glutathione (GSH) metabolism, and inducing glutathione S-transferase (GST) activity, particularly isoforms involved in detoxifying lipid peroxidation products such as 4-hydroxynonenal (4-HNE)

For these reasons, the peptide is commonly included in anti-aging skin products [10, 11]

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