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DNA methylation profiling revealed that prostate cancer-associated fibroblasts (CAFs) are characterized by the epigenetic silencing of the RAS inhibitor, the RAS protein activatorlike 3 (RASAL3), and therefore possess an activation of oncogenic RAS signaling

Targeting ferroptosis suppresses osteocyte glucolipotoxicity and alleviates diabetic osteoporosis

Conversely, inhibition of diglyceride acyltransferase 2 with antisense oligonucleotides in db/db mice fed a methionine and choline-deficient diet-reduced hepatic steatosis, but augmented hepatic inflammation, fibrosis, and apoptosis [71]

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