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Sometimes referred to as the "pregnancy mask" or general dullness, these changes are often driven by hormones and oxidative stress

Symptoms in males can include: Decrease in sex drive Difficulty getting or maintaining an erection Decrease in muscle mass Bone weakness Breast tissue development Hair loss Difficulty with memory and concentration Decrease in testicle size Decrease in semen production causing fertility problems Hypogonadism can occur if: Your testes are not making enough testosterone Your brain does not signal the testes to make enough testosterone You are taking medication or are undergoing cancer treatment that changes the amount of testosterone that your body makes Abnormal testosterone levels can be caused by various factors, including age, lifestyle, and certain medical conditions

Further, it inhibits 4-hydroxynoneal, a molecule produced in the body that negatively impacts cellular growth

These compounds appear to be effective in extracellular space, where the concentration of antioxidant enzymes is usually much lower than in the intracellular environment