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The ADA Standards of Care 2024 acknowledge oxidative stress as a mechanistic contributor to diabetic complications but stop short of recommending specific antioxidant supplementation due to inconsistent clinical outcomes data

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Melatonin exerts protective effects in an ILC2-biased model of allergic airways disease, even in the presence of canonical receptor blockade To determine whether the protective effects of melatonin extended beyond allergen-driven disease, we next employed an ILC2-biased IL-33 model of allergic airways inflammation ( Figure 2A )