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With age, Nicotinamide Adenine Dinucleotide (or NAD) levels naturally decline, slowing down metabolism and making weight loss harder

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Nutritional Neuroscience, 25 (8), 1704-1730

Another possible explanation for the higher percentage of more mature adult-born neurons in males compared with females at two weeks may involve competition and/or apoptosis resulting in part from the greater attrition from one to two weeks in males, which may impact the survival rate of new neurons (Bergami and Berninger, 2012)