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We have eagerly awaited seeing the actual results since the sponsor company (Novo Nordisk) issued a press release in August that proclaimed a 20% relative reduction of cardiovascular death, heart attack or stroke, the primary endpoint of the trial

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doi:10.1016/j.spen.2013.10.008CrossRefGoogle ScholarPubMed Krhenbhl, S, Brandner, S, Kleinle, S, Liechti, S, Straumann, D

Therefore, DON treatment can not only reduce the self-renewal potential and metastatic ability of pancreatic ductal adenocarcinoma (PDAC) tumor cells but also lead to extensive remodeling of the tumor extracellular matrix (ECM), promoting the infiltration and activation of CD8 + T cells (Sharma et al., 2020)