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In senescent cells, FOXO4 binding limits p53s pro-apoptotic function

The release of MPO during the activation of neutrophils is related to airway hyperreactivity (41), which can catalyze the reaction between hydrogen peroxide and chloride to produce hypochlorous acid with higher activity and stronger toxicity, which is considered to be a significant marker of inflammatory response (42), while nitrite formed by nitric oxide oxidation is an important substrate for MPO production (43)

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A pilot study of the effect of inhaled buffered reduced glutathione on the clinical status of patients with cystic fibrosis